AB1491 CONJUNCTIVAL BIOPSY IN OCULAR CICATRICIAL PEMPHIGOID, ARE THERE PATTERNS TO PREDICT SEQUELAE?

Background Ocular cicatricial pemphigoid (OCP) is a chronic, immune-mediated, fibrosing disease that can lead to blindness. The diagnosis clinical and/or based on the results of conjunctival biopsy. There are no studies have studied histopathological findings and risk sequelae in this entity. Objectives describe biopsies from patients with OCP identify characteristics may be associated greater fibrosis sequelae. Methods A retrospective, multicentre study was carried out. Patients over 18 years age by pathology were selected. Medical records reviewed demographic, clinical, biopsy data collected. To assess whether histology or lesser (determined Foster’s stages), divided into two groups: early stages (0 1) versus 2, 3, 4. variables between groups compared. groups. determine immunofluorescence deposits time, Cox multivariate analysis performed. Sequelae defined as multicomponent variable consisting queratopia, xerophthalmia, entropion, trichiasis, cataracts, glaucoma, vitreous opacity, retinal scars, synechiae, Results Fifty-seven POC diagnosed included. mean presentation at 62.7 (SD 13.2) 41 (71.9%) women. follow-up time 1.5 (2.9). Foster (stages 0 50.9%. presence rounded spindle-shaped mast cells stages, while eosinophils later diagnosis. In IgM more frequent IgG ones, predominant linear pattern (92%) (Table 1). During follow-up, 15 (27.3%) developed regression analysis, IgA resulted during period for development sequelae; positive: HR 10.8, IC 95% 1.3 92.9 (p-value 0.03). positive; 0.2, 0.02 0.08); positive 0.4, 0.1 2.3 0.29) C3 1.7 0.14) Conclusion This one largest rheumatologic series has evaluated provides information possible role different antibody could play mucosa. Future larger prospective help define detection patterns give us accurate idea prognosis treatment these patients. Table 1. Biopsy´s according stage. Total N= 57 Early y 29 (50.9%) Advanced (2, 3 4) 28 (49.1%) P value Hipotrofic sectors, n (%) 30 (65.2) 1 Decreased absent goblet cells, 40 (76.9) 21 (80.7) 19 (73.1) 0.74 Superficial parakeratosis, 32 (58.2) (64.3) 14 (51.8) 0.35 Lymphoplasmacytic infiltrates, 48 (94.1) 22 (91.7) 26 (96.3) 0.59 Infiltrates mucosa-submucosa chorion-epithelial interface, 37 (88.1) (88.2) (88) T lymphocytes, 34 (85) 12 (75) 0.19 B Rounded 35 (67.3) (81.5) 13 (52) 0.04 Spindle (38.3) (54.5) 6 (24) 0.03 Degranulating (40) 9 (45) (36) 0.54 Monocytes/Neutrophils, (80) 11 (73.3) (84) 0.44 Eosinophils, (37.8) 2 (14.3) (52.2) Fibrosis, 27 (67.5) (56.2) 0.3 Lymph ectasia, 43 (82.7) 23 (85.2) 20 0.72 Deposits (linear) 49 (92.4) (96.4) 0.33 - positive, 25 (43.8) (31) 16 (57.1) (36.8) (51.7) (21.4) 36 (63.2) (72.4) (53.6) 0.14 17 (29.8) (20.7) (39.3) 0.12 REFERENCES: NIL. Acknowledgements: Disclosure Interests None Declared.